Supply Chain Optimization

Services

Supply Chain Optimization

We collaborate with your team to translate product forecasts into executable capacityplans, tech-transfers and registration timelines. Our approach blends demand modeling,supplier segmentation, CMO sourcing strategies and regulatory sequencing so launchesaren’t constrained by supply. We deliver replicable playbooks that convert tacticaldecisions into portfolio-level resilience.

Cross-functional Technical Product Team & Capacity Plan for Complex ADC

Enablement of on-time global launch for a complex ADC by mobilizing a Technical Product Team and an integrated 12-quarter capacity plan.

Insights

Challenge: A global biopharma client was launching acomplex ADC composed of antibody, linker and small-molecule components. Capital constraints and staggered approvals left launch capacity insufficient across raw materials, inputs, conjugation and fill/finish.

Approach: We mobilized the first TPT: Technical Product Leader, Demand Forecasters, Supply Lead, CMC/Regulatory, Quality, Manufacturing, and Tech-Transfer leads. We back-calculated demand by phase, identified nine additional nodes required across the value chain, assessed sourcing options (greenfield, internal repurpose, arms-length CMO slots, strategic co-investment) and established tech-transfer execution metrics and reporting cadence.

Impact: Client executed site additions and partner slot buys per the TPT roadmap and achieved on-time, in-full global launch without product supply being a gating constraint. The TPT operating model was adopted portfolio-wide.

Inventory & Dual-Sourcing Redesign for Global Launch Readiness

Reduction of stockout risk and improved launch readinessfor a geographically dispersed portfolio by redesigninginventory and dual-sourcing strategies.

Insights

Challenge: A confidential portfolio preparing staggered country launches had uneven safety-stock policies and single-source dependencies for several critical inputs. Country-level regulatory timing variability and long supplier lead times exposed launches to elevated stockout and bridging-stock risk, threatening launch timelines and working capital.

Approach: We segmented SKUs and suppliers by criticality and impact, created demand-driven safety-stock rules tied to country approval risk, and developed dual-sourcing playbooks for priority inputs. Scenario models simulated regulatory delays and supplier failures to quantify contingency capacity needs. We also established contractual sourcing options (backstop CMO slots and prioritized internal capacity bundles) and built an operational cadence for supplier performance monitoring and rapid slot activation.

Impact: The client reduced single-source exposure on prioritized inputs, had contingency capacity plans in place for all launch-critical SKUs, and gained clearer inventory/bridging-stock forecasts for portfolio launches—significantly lowering the likelihood of launch-blocking stockouts and improving supply confidence with product strategy stakeholders.

Supply Chain and Network Strategy for a Pre- Launch Gene Therapy Company

Development of a flexible 5-year supply strategy that cut capacity costs by 25% while reducing supply risk and supporting commercial and clinical gene therapy demand.

Insights

Challenge: Client wanted to balance product cost and supply risk as it transitioned from clinical to commercial manufacturing for a complex gene therapy launch. The goal was to develop a strategy that evolved with the company’s needs – (1) managing dependence on CMOs for drug product and vector manufacture, (2) reducing operational complexity, (3) gaining flexibility in managing capacity expansion, and (4) reducing supply risk for commercial and clinical demand.

Approach: Analyzed the current (as-is) supply network for cost, risk, flexibility, and opportunities, and created options for future supply networks, demand forecasts and scenarios. Developed an investment model for the next five years to address both drug and vector manufacturing.

Impact: Recommended an evolving supply network strategy to meet product demand while balancing cost and risk and retaining flexibility. Ultimately, this led to a clear, 5-year network strategy backed by robust analysis that could be set in motion immediately, and that would reduce the cost of maintaining manufacturing capacity by 25% while managing supply risk and maintaining required service levels.

Services